Pregabalin 75mg + Duloxetine 20mg

Pregabalin 75mg + Duloxetine 20mg — Uses and Benefits

This combination is mainly prescribed for chronic nerve pain conditions where both pain relief and mood/nerve stabilisation are needed.

WHAT THIS MEDICINE IS USED FOR

• Diabetic nerve pain (peripheral neuropathy)
• Nerve pain after shingles (post-herpetic neuralgia)
• Fibromyalgia-related widespread pain
• Chronic musculoskeletal pain with a nerve component
• Anxiety symptoms occurring alongside chronic pain

HOW IT WORKS

• Pregabalin reduces abnormal electrical activity in damaged nerves, easing pain and tingling
• Duloxetine increases serotonin and noradrenaline levels in the brain and spinal cord, which helps dampen pain signals
• Together they target pain from two different pathways for better relief

WHAT IT IS NOT USED FOR

• Not for sudden, short-term pain like headache or injury
• Not a first-line treatment for general anxiety or depression alone
• Not meant for muscle spasm relief
• Not to be used as a sleep aid, though drowsiness may occur

How to Use Pregabalin 75mg + Duloxetine 20mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually once or twice a day
• Swallow the capsule/tablet whole with water
• Can be taken with or without food, but taking it consistently at the same time helps
• Do not stop suddenly without consulting your doctor, as it may cause withdrawal-like symptoms
• It may take a few weeks to feel full benefit

IF YOU MISS A DOSE

• Take it as soon as you remember
• If it is almost time for your next dose, skip the missed one and continue as usual
• Do not take a double dose to make up for a missed one

STORAGE

• Store at room temperature, away from direct heat and sunlight
• Keep in its original packaging until use
• Keep out of reach and sight of children
• Do not use after the expiry date printed on the pack

Pregabalin 75mg + Duloxetine 20mg — Side Effects

COMMON SIDE EFFECTS

• Dizziness
• Drowsiness or sleepiness
• Dry mouth
• Nausea
• Constipation
• Weight gain
• Blurred vision

LESS COMMON SIDE EFFECTS

• Swelling of hands or feet
• Difficulty concentrating
• Increased sweating
• Reduced appetite
• Sexual difficulties
• Trouble sleeping

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Signs of allergic reaction such as rash, swelling of face/lips/tongue, difficulty breathing
• Thoughts of self-harm or worsening mood
• Severe dizziness or fainting
• Signs of liver problems like yellowing of eyes/skin, dark urine
• Unusual bleeding or bruising
• Severe muscle stiffness, high fever, confusion (signs of serotonin syndrome)
• Sudden vision changes or eye pain

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Pregabalin 75mg + Duloxetine 20mg — Safety Information and Precautions

This is a prescription-only medicine in India and should be used strictly under a doctor's supervision.

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to pregabalin, duloxetine, or any other ingredient in the product
• Have uncontrolled narrow-angle glaucoma
• Have severe kidney or liver disease without medical advice
• Are taking or have recently taken MAO inhibitors

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have a history of depression, anxiety, or suicidal thoughts
• Have heart disease or low blood pressure
• Have a history of seizures
• Are pregnant, planning pregnancy, or breastfeeding
• Have a history of alcohol or substance misuse
• Have kidney or liver problems

MEDICINES THAT CAN INTERACT

• Other antidepressants (SSRIs, SNRIs, tricyclics)
• MAO inhibitors
• Blood thinners like warfarin
• Other sedatives, opioids, or sleeping pills
• Alcohol
• NSAIDs or aspirin (increased bleeding risk)

FREQUENTLY ASKED QUESTIONS

Can I drink alcohol while taking this medicine?

No, alcohol can increase drowsiness and other side effects, so it should be avoided.

Will this medicine make me sleepy?

Yes, it can cause drowsiness, so avoid driving or operating machinery until you know how it affects you.

Can I stop this medicine once my pain improves?

• No, do not stop without your doctor's advice as sudden stopping can cause withdrawal symptoms.
• Doctor ya pharmacist se salah lein.