Rifampicin 100 mg + Isoniazid 100 mg

Rifampicin 100 mg + Isoniazid 100 mg — Uses and Benefits

This combination medicine is mainly used to treat tuberculosis (TB), a bacterial infection that most often affects the lungs but can also affect other parts of the body.

WHAT THIS MEDICINE IS USED FOR

• Treatment of pulmonary (lung) tuberculosis
• Treatment of extra-pulmonary tuberculosis, as advised by the doctor
• Used as part of a multi-drug regimen for TB, not alone

HOW IT WORKS

• Rifampicin blocks an enzyme the TB bacteria need to make RNA, stopping their growth
• Isoniazid blocks formation of the bacterial cell wall, killing the TB bacteria
• Together they act on different stages of bacterial growth, making treatment more effective and reducing chances of resistance

WHAT IT IS NOT USED FOR

• Not used for viral infections such as cold, flu, or COVID-19
• Not used for ordinary bacterial infections unrelated to TB
• Not a painkiller or fever medicine
• Should not be used to prevent TB unless specifically prescribed for preventive therapy

How to Use Rifampicin 100 mg + Isoniazid 100 mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually once daily
• Best taken on an empty stomach, at least 30 minutes before food, unless your doctor advises otherwise
• Swallow the tablet with a full glass of water
• Do not stop the medicine early even if you feel better; complete the full course as advised
• Take at the same time every day to help you remember

IF YOU MISS A DOSE

• Take the missed dose as soon as you remember
• If it is almost time for the next dose, skip the missed one and continue as usual
• Do not take a double dose to make up for a missed one
• Missing doses can make TB treatment less effective, so try not to skip

STORAGE

• Store at room temperature, away from direct sunlight and moisture
• Keep in the original pack until it is time to take it
• Keep out of reach of children
• Do not use after the expiry date printed on the pack

Rifampicin 100 mg + Isoniazid 100 mg — Side Effects

COMMON SIDE EFFECTS

• Nausea or vomiting
• Loss of appetite
• Stomach upset
• Orange-red discoloration of urine, sweat, tears, or saliva (harmless)

LESS COMMON SIDE EFFECTS

• Headache
• Dizziness
• Diarrhoea
• Skin rash or itching
• Joint pain

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Yellowing of eyes or skin, dark urine (signs of liver problems)
• Severe stomach pain
• Numbness, tingling, or burning sensation in hands or feet
• Unusual bleeding or bruising
• Severe skin reaction with blisters or peeling
• Difficulty breathing, swelling of face or throat (allergic reaction)
• Persistent vomiting or unexplained tiredness

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Rifampicin 100 mg + Isoniazid 100 mg — Safety Information and Precautions

This medicine is available only with a doctor's prescription in India. It should be taken under supervision of a TB treatment programme or physician.

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to rifampicin, isoniazid, or any other ingredient
• Have severe active liver disease, unless your doctor decides benefits outweigh risks
• Have had a previous severe reaction to anti-TB drugs

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have any liver or kidney disease
• Drink alcohol regularly
• Are pregnant, planning pregnancy, or breastfeeding
• Have diabetes, as it can increase risk of nerve side effects
• Are taking any other medicines, including herbal or over-the-counter products
• Use hormonal contraceptives, as this medicine may reduce their effectiveness

MEDICINES THAT CAN INTERACT

• Oral contraceptive pills
• Blood thinners like warfarin
• Anti-epileptic medicines
• HIV medicines (protease inhibitors, some antiretrovirals)
• Diabetes medicines
• Other medicines that affect the liver

FREQUENTLY ASKED QUESTIONS

Can I stop the medicine once I feel better?

No, stopping early can make TB come back stronger and drug-resistant; always complete the full course as advised by your doctor.

Will this medicine change the colour of my urine?

Yes, harmless orange-red discoloration of urine, sweat, and tears is common and not a cause for worry.

Can I drink alcohol while on this medicine?

• It is best to avoid alcohol as it increases the risk of liver side effects during TB treatment.
• Doctor ya pharmacist se salah lein.