Glibenclamide 5mg + Metformin 500mg + Pioglitazone 15mg

Glibenclamide 5mg + Metformin 500mg + Pioglitazone 15mg — Uses and Benefits

This combination medicine is used to treat type 2 diabetes mellitus in adults when blood sugar is not controlled adequately by diet, exercise, or a single medicine alone.

WHAT THIS MEDICINE IS USED FOR

• Controlling high blood sugar levels in type 2 diabetes
• Used when a single anti-diabetic medicine is not enough
• Helps reduce long-term complications of diabetes when blood sugar is well managed

HOW IT WORKS

• Glibenclamide stimulates the pancreas to release more insulin
• Metformin reduces sugar production by the liver and improves insulin sensitivity
• Pioglitazone improves how the body's cells respond to insulin, especially in muscle and fat tissue
• Together they lower blood sugar through three different mechanisms

WHAT IT IS NOT USED FOR

• Not used for type 1 diabetes
• Not used for diabetic ketoacidosis or diabetic coma
• Not a treatment for weight loss
• Not to be used during pregnancy for diabetes control unless specifically advised

How to Use Glibenclamide 5mg + Metformin 500mg + Pioglitazone 15mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually with breakfast or the first main meal of the day
• Swallow the tablet whole with water; do not crush or chew unless advised
• Take at the same time each day for best results
• Continue healthy diet and regular exercise along with this medicine
• Do not stop the medicine suddenly without consulting your doctor

IF YOU MISS A DOSE

• Take it as soon as you remember, unless it is almost time for your next dose
• If it is close to the next dose, skip the missed dose and continue your normal schedule
• Do not take a double dose to make up for a missed one
• If you frequently miss doses, discuss a reminder system with your doctor or pharmacist

STORAGE

• Store at room temperature, away from direct sunlight and moisture
• Keep in the original packaging until ready to use
• Keep out of reach of children and pets
• Do not use after the expiry date printed on the pack

Glibenclamide 5mg + Metformin 500mg + Pioglitazone 15mg — Side Effects

COMMON SIDE EFFECTS

• Nausea or upset stomach
• Diarrhoea
• Loss of appetite
• Metallic taste in mouth
• Weight gain
• Mild swelling of feet or ankles

LESS COMMON SIDE EFFECTS

• Headache
• Dizziness
• Low blood sugar (hypoglycemia), especially if meals are skipped
• Skin rash or itching

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Signs of severe low blood sugar such as sweating, shakiness, confusion, or fainting
• Yellowing of skin or eyes, dark urine (signs of liver problems)
• Unusual tiredness, muscle pain, difficulty breathing (rare sign of lactic acidosis)
• Sudden weight gain, swelling, or shortness of breath (possible heart failure)
• Bone fractures with minor injury
• Signs of severe allergic reaction such as facial swelling, breathing difficulty, or widespread rash

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Glibenclamide 5mg + Metformin 500mg + Pioglitazone 15mg — Safety Information and Precautions

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to glibenclamide, metformin, pioglitazone, or sulfonamide medicines
• Have type 1 diabetes or diabetic ketoacidosis
• Have severe kidney or liver disease
• Have heart failure or a history of bladder cancer
• Are pregnant or breastfeeding, unless specifically advised by your doctor

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have any kidney, liver, or heart problems
• Are scheduled for surgery or an X-ray with contrast dye
• Drink alcohol regularly
• Have a history of low blood sugar episodes
• Have osteoporosis or are at risk of fractures

MEDICINES THAT CAN INTERACT

• Other diabetes medicines or insulin
• Steroids or diuretics (water pills)
• Certain blood pressure medicines
• NSAIDs (pain relievers like ibuprofen)
• Alcohol
• Medicines affecting liver enzymes

FREQUENTLY ASKED QUESTIONS

Can I drink alcohol while taking this medicine?

It is best to avoid or limit alcohol as it increases the risk of low blood sugar and lactic acidosis.

Will this medicine cause weight gain?

Some weight gain and fluid retention can occur, especially with pioglitazone; tell your doctor if it is significant.

Can I take this medicine if I am pregnant?

• This combination is generally not recommended during pregnancy; consult your doctor for safer alternatives.
• This medicine is available only with a valid doctor's prescription in India. Doctor ya pharmacist se salah lein.