Isoniazid 100 mg + Pyrazinamide 50 mg + Rifampicin 300 mg

Isoniazid 100 mg + Pyrazinamide 50 mg + Rifampicin 300 mg — Uses and Benefits

This combination medicine is used to treat active tuberculosis (TB) infection, usually during the intensive phase of treatment.

WHAT THIS MEDICINE IS USED FOR

• Treatment of pulmonary and certain extra-pulmonary forms of tuberculosis
• Used as part of a multi-drug regimen prescribed by a TB specialist or under national TB programmes
• Helps prevent the TB bacteria from developing resistance to single drugs

HOW IT WORKS

• Isoniazid and Rifampicin kill actively multiplying TB bacteria
• Pyrazinamide works well in acidic environments, killing bacteria hiding inside cells
• Together, the three drugs attack the bacteria through different mechanisms, making treatment more effective and reducing chances of drug resistance

WHAT IT IS NOT USED FOR

• Not used for common cold, cough, or ordinary bacterial infections
• Not a treatment for viral infections
• Not to be used for latent TB without doctor's specific advice
• Not meant for self-medication or short-term use without diagnosis

How to Use Isoniazid 100 mg + Pyrazinamide 50 mg + Rifampicin 300 mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually once daily
• Preferably take on an empty stomach, at least 30 minutes before food, unless your doctor advises otherwise
• Swallow the tablet whole with a glass of water; do not crush or chew unless instructed
• Do not stop the medicine even if you feel better - complete the full course as advised
• Avoid alcohol during treatment as it increases risk of liver problems

IF YOU MISS A DOSE

• Take the missed dose as soon as you remember
• If it is almost time for the next dose, skip the missed one and continue your normal schedule
• Do not take a double dose to make up for the missed one
• Try to take doses at the same time each day to maintain consistency

STORAGE

• Store at room temperature, away from direct heat, sunlight and moisture
• Keep in original packaging until ready to use
• Keep out of reach and sight of children
• Do not use after the expiry date printed on the pack

Isoniazid 100 mg + Pyrazinamide 50 mg + Rifampicin 300 mg — Side Effects

COMMON SIDE EFFECTS

• Nausea or vomiting
• Loss of appetite
• Stomach upset
• Orange-red discoloration of urine, sweat, tears or saliva (harmless)

LESS COMMON SIDE EFFECTS

• Tingling or numbness in hands and feet
• Joint pain
• Mild skin rash or itching
• Headache or dizziness

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Yellowing of skin or eyes, dark urine (signs of liver damage)
• Severe stomach pain or persistent vomiting
• Unexplained fever, bruising or bleeding
• Severe skin rash, blistering, or peeling skin
• Vision changes or blurred vision
• Signs of severe allergic reaction such as swelling of face/throat, difficulty breathing

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Isoniazid 100 mg + Pyrazinamide 50 mg + Rifampicin 300 mg — Safety Information and Precautions

This is a prescription-only medicine in India and should be taken only under the supervision of a qualified doctor as part of a proper TB treatment plan.

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to Isoniazid, Pyrazinamide, Rifampicin, or any other ingredient
• Have severe active liver disease
• Have acute gout (due to Pyrazinamide)

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have any history of liver or kidney disease
• Are pregnant, planning pregnancy, or breastfeeding
• Consume alcohol regularly
• Have diabetes
• Have a history of seizures or nerve problems
• Are taking other medications, including herbal or over-the-counter products

MEDICINES THAT CAN INTERACT

• Oral contraceptives (Rifampicin can reduce their effectiveness)
• Blood thinners like Warfarin
• Diabetes medicines
• Anti-epileptic drugs like Phenytoin
• Other liver-affecting medicines
• HIV/antiretroviral medicines

FREQUENTLY ASKED QUESTIONS

Can I drink alcohol while taking this medicine?

No, alcohol should be avoided as it increases the risk of liver damage during TB treatment.

Will this medicine change the color of my urine?

Yes, orange-red discoloration of urine, sweat, and tears is common and harmless.

Can I stop the medicine once I feel better?

• No, you must complete the full course as prescribed, even if symptoms improve, to prevent drug resistance and relapse.
• Doctor ya pharmacist se salah lein.