Rifampicin 450mg + Isoniazid 300mg

Rifampicin 450mg + Isoniazid 300mg — Uses and Benefits

This medicine is used to treat active tuberculosis (TB) infection, usually as part of a multi-drug regimen.

WHAT THIS MEDICINE IS USED FOR

• Treatment of pulmonary and certain forms of extra-pulmonary tuberculosis
• Used in combination with other anti-TB drugs as part of a complete treatment course
• Sometimes used for prevention of TB in high-risk contacts, as decided by the doctor

HOW IT WORKS

• Rifampicin stops the TB bacteria from making proteins needed to survive and multiply
• Isoniazid blocks the bacteria from building their protective outer wall
• Together they act on bacteria at different stages, reducing the chance of drug resistance

WHAT IT IS NOT USED FOR

• Not used for common cold, flu, or ordinary bacterial infections
• Not a treatment for viral infections
• Not for short-term or occasional use — it requires a full prescribed course, often several months

How to Use Rifampicin 450mg + Isoniazid 300mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually once daily
• Take on an empty stomach, at least 30 minutes before food, unless your doctor advises otherwise
• Swallow the tablet whole with water; do not crush or chew unless instructed
• Do not stop the medicine even if you feel better — complete the full course as advised
• Take at the same time each day to maintain a regular routine

IF YOU MISS A DOSE

• Take the missed dose as soon as you remember
• If it is almost time for the next dose, skip the missed one and continue as usual
• Do not take a double dose to make up for a missed one
• Missing doses can allow bacteria to become resistant, so try not to skip doses

STORAGE

• Store at room temperature, away from direct sunlight and moisture
• Keep in the original container, tightly closed
• Keep out of reach of children
• Do not use beyond the expiry date printed on the pack

Rifampicin 450mg + Isoniazid 300mg — Side Effects

COMMON SIDE EFFECTS

• Nausea or vomiting
• Loss of appetite
• Stomach upset
• Orange-red discolouration of urine, sweat, or tears (harmless)

LESS COMMON SIDE EFFECTS

• Headache
• Dizziness
• Numbness or tingling in hands or feet
• Mild skin rash or itching

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Yellowing of eyes or skin, dark urine (signs of liver problems)
• Severe stomach pain or persistent vomiting
• Unexplained bleeding or bruising
• Fever, chills, or flu-like symptoms with breathlessness
• Severe skin reaction with blisters or peeling
• Vision changes or blurred vision
• Signs of severe allergic reaction such as swelling of face/lips/throat, difficulty breathing

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Rifampicin 450mg + Isoniazid 300mg — Safety Information and Precautions

This is a prescription-only medicine in India and should not be used without a doctor's prescription and monitoring.

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to rifampicin, isoniazid, or any other ingredient in this medicine
• Have severe active liver disease
• Have had liver damage from isoniazid or rifampicin in the past

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have any liver or kidney disease
• Drink alcohol regularly
• Are pregnant, planning pregnancy, or breastfeeding
• Have diabetes or nerve problems
• Are taking oral contraceptives, as this medicine can reduce their effectiveness
• Have a history of seizures or mental health conditions

MEDICINES THAT CAN INTERACT

• Oral contraceptive pills
• Blood thinners such as warfarin
• Antiretroviral drugs used for HIV
• Antifungal medicines like ketoconazole
• Antacids (can reduce absorption if taken together)
• Other medicines affecting the liver

FREQUENTLY ASKED QUESTIONS

Can I stop this medicine once my symptoms improve?

No, stopping early can cause the infection to return and lead to drug-resistant TB; complete the full course as prescribed.

Will this medicine change the colour of my urine?

Yes, orange-red discolouration of urine, sweat, and tears is common and harmless.

Can I drink alcohol while taking this medicine?

• It is best to avoid alcohol as it increases the risk of liver damage during treatment.
• Doctor ya pharmacist se salah lein.