Rifampicin 60 mg + Isoniazid 30 mg + Pyrazinamide 150 mg

Rifampicin 60 mg + Isoniazid 30 mg + Pyrazinamide 150 mg — Uses and Benefits

This combination medicine is used in the treatment of active tuberculosis (TB) infection, usually during the initial intensive phase of treatment.

WHAT THIS MEDICINE IS USED FOR

• Treatment of pulmonary (lung) tuberculosis
• Treatment of certain forms of extra-pulmonary tuberculosis, as advised by doctor
• Used as part of a multi-drug anti-TB regimen, never alone

HOW IT WORKS

• Rifampicin stops TB bacteria from multiplying by blocking their ability to make essential proteins
• Isoniazid damages the bacterial cell wall, killing the bacteria
• Pyrazinamide works especially well in acidic environments inside infected tissue, killing dormant bacteria
• Together they act on bacteria at different stages, lowering the risk of drug resistance

WHAT IT IS NOT USED FOR

• Not used for viral infections like cold, flu or COVID-19
• Not used for ordinary bacterial infections such as UTI or throat infection
• Not a painkiller or fever medicine
• Not to be used for latent TB without doctor's specific advice

How to Use Rifampicin 60 mg + Isoniazid 30 mg + Pyrazinamide 150 mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually once daily
• Best taken on an empty stomach, at least 30 minutes before food, unless your doctor advises otherwise
• Swallow the tablet whole with a full glass of water
• Do not skip doses or stop early even if you feel better - complete the full course as advised
• Take at the same time each day to maintain regularity
• Avoid alcohol during treatment as it increases risk of liver damage

IF YOU MISS A DOSE

• Take the missed dose as soon as you remember
• If it is almost time for the next dose, skip the missed one and continue as usual
• Do not take a double dose to make up for a missed one
• Try to maintain a consistent daily routine to avoid missed doses

STORAGE

• Store at room temperature, away from direct sunlight and moisture
• Keep in original packaging until ready to use
• Keep out of reach and sight of children
• Do not use after the expiry date printed on the pack

Rifampicin 60 mg + Isoniazid 30 mg + Pyrazinamide 150 mg — Side Effects

COMMON SIDE EFFECTS

• Nausea and vomiting
• Loss of appetite
• Stomach upset
• Orange-red discoloration of urine, saliva or tears (harmless)
• Joint pain

LESS COMMON SIDE EFFECTS

• Headache
• Dizziness
• Skin rash or itching
• Numbness or tingling in hands and feet
• Mild fever

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Yellowing of eyes or skin, dark urine (signs of liver problem)
• Severe stomach pain with vomiting
• Unusual tiredness or weakness
• Easy bruising or unusual bleeding
• Severe skin reaction with blisters or peeling
• Difficulty breathing, swelling of face or throat (allergic reaction)
• Vision changes or eye pain
• Persistent fever or flu-like symptoms

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Rifampicin 60 mg + Isoniazid 30 mg + Pyrazinamide 150 mg — Safety Information and Precautions

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to rifampicin, isoniazid, pyrazinamide or any other ingredient
• Have severe active liver disease
• Have had previous drug-induced jaundice or liver damage from these medicines
• Have acute gout

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have any liver or kidney disease
• Are pregnant, planning pregnancy, or breastfeeding
• Drink alcohol regularly
• Have diabetes
• Have a history of seizures or nerve problems
• Are taking any other medicines, including herbal or over-the-counter products

MEDICINES THAT CAN INTERACT

• Oral contraceptive pills (this medicine may reduce their effectiveness)
• Blood thinners like warfarin
• Diabetes medicines
• Other medicines that affect the liver
• HIV medicines and certain antifungal or antibiotic drugs
• Antacids (may reduce absorption; take at a different time)

FREQUENTLY ASKED QUESTIONS

Can I stop the medicine once my symptoms improve?

No, stopping early can lead to drug-resistant TB; complete the full course as prescribed by your doctor.

Will this medicine change the colour of my urine?

Yes, orange-red discoloration of urine, sweat and tears is common and harmless.

Can I drink alcohol while on this treatment?

• No, alcohol increases the risk of liver damage and should be avoided during treatment.
• This medicine is available only with a valid doctor's prescription in India. Doctor ya pharmacist se salah lein.