Sacubitril 49mg + Valsartan 51mg

Sacubitril 49mg + Valsartan 51mg — Uses and Benefits

This combination medicine is mainly prescribed for people with chronic heart failure, especially when the heart's pumping ability is reduced.

WHAT THIS MEDICINE IS USED FOR

• To reduce the risk of hospitalisation due to worsening heart failure
• To reduce the risk of death from heart-related causes in heart failure patients
• Used long-term as part of overall heart failure management, often with other medicines like beta-blockers or diuretics

HOW IT WORKS

• Sacubitril blocks an enzyme called neprilysin, which increases levels of natural substances that help the heart and blood vessels
• Valsartan blocks angiotensin II, a hormone that narrows blood vessels, helping vessels relax and lowering blood pressure
• Together they reduce strain on the heart and improve its ability to pump blood

WHAT IT IS NOT USED FOR

• Not used for treating acute chest pain or heart attacks
• Not a first-choice treatment for high blood pressure alone unless specifically advised
• Not meant for short-term or occasional use; it is a long-term maintenance treatment
• Not to be used in pregnancy

How to Use Sacubitril 49mg + Valsartan 51mg

HOW TO TAKE IT

• Take exactly as prescribed by your doctor, usually twice a day
• Can be taken with or without food
• Swallow the tablet with water; do not crush or chew unless your doctor advises
• Do not stop taking it suddenly without consulting your doctor, even if you feel better
• Continue other heart failure medicines as advised alongside this one

IF YOU MISS A DOSE

• Take it as soon as you remember
• If it is almost time for your next dose, skip the missed dose
• Do not take a double dose to make up for a missed one
• If you miss doses often, set reminders or inform your doctor

STORAGE

• Store at room temperature, away from direct sunlight and moisture
• Keep in the original pack until ready to use
• Keep out of reach of children and pets
• Do not use beyond the expiry date printed on the pack

Sacubitril 49mg + Valsartan 51mg — Side Effects

COMMON SIDE EFFECTS

• Low blood pressure (dizziness, light-headedness)
• High potassium levels in blood
• Cough
• Tiredness or weakness
• Dizziness when standing up

LESS COMMON SIDE EFFECTS

• Kidney function changes
• Nausea
• Diarrhoea
• Headache

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Swelling of face, lips, tongue or throat with difficulty breathing (angioedema)
• Severe dizziness or fainting
• Signs of very high potassium such as muscle weakness or irregular heartbeat
• Little or no urine output, suggesting kidney problems
• Yellowing of skin or eyes

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

Sacubitril 49mg + Valsartan 51mg — Safety Information and Precautions

This medicine is available only with a valid doctor's prescription in India.

DO NOT TAKE THIS MEDICINE IF YOU

• Are pregnant or planning pregnancy
• Have had an allergic reaction to sacubitril, valsartan, or similar medicines (ACE inhibitors, ARBs)
• Have a history of angioedema related to ACE inhibitors or ARBs
• Are currently taking an ACE inhibitor (needs a gap between switching medicines)
• Have severe liver disease

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have kidney disease or are on dialysis
• Have low blood pressure or are prone to dizziness
• Have diabetes, especially if taking certain diabetes medicines
• Have high potassium levels
• Are breastfeeding

MEDICINES THAT CAN INTERACT

• ACE inhibitors (do not use together)
• Other blood pressure medicines
• Potassium supplements or potassium-sparing diuretics
• Certain diabetes medicines like aliskiren-containing products
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen
• Lithium

FREQUENTLY ASKED QUESTIONS

Can I take this medicine for high blood pressure only?

It is mainly prescribed for heart failure; your doctor will decide if it suits you for blood pressure control.

How long do I need to take this medicine?

It is usually a long-term treatment for heart failure, so continue as long as your doctor advises.

Will this medicine cure my heart failure completely?

• No, it helps manage symptoms and reduce complications, but it does not cure the underlying heart condition.
• Doctor ya pharmacist se salah lein.