ISTamet 50mg/500mg Tablet

Uses and Benefits of ISTamet 50mg/500mg Tablet (Sitagliptin 50mg + Metformin 500mg)

Sitagliptin 50mg + Metformin 500mg is a fixed-dose combination tablet used for the effective management of Type 2 Diabetes Mellitus (T2DM) in adults.

Indicated For:

Type 2 Diabetes Mellitus — primary management

Patients inadequately controlled on Metformin alone

As an add-on when diet and exercise are not sufficient

Reduction of HbA1c (3-month average blood sugar levels)

Key Benefits:

Dual-Action Formula — Works through two different mechanisms simultaneously for superior blood sugar control

Low Risk of Hypoglycemia — Insulin is stimulated only when blood glucose is elevated, making it safer than sulfonylureas

Weight Neutral — Does not cause weight gain; may support mild weight loss in some patients

Cardiovascular Safety — Proven safe for patients with heart conditions (TECOS trial)

Beta-Cell Protection — Helps preserve the natural insulin-producing function of the pancreas over time

Improved Compliance — Two medicines in one tablet means a simpler daily routine and fewer pills

Side Effects of ISTamet 50mg/500mg Tablet (Sitagliptin 50mg + Metformin 500mg)

Nausea or upset stomach

Diarrhea or loose stools

Stomach pain or bloating

Headache

Runny or stuffy nose

Sore throat or upper respiratory symptoms

Less Common Side Effects:

Urinary tract infection (burning or pain during urination)

Fatigue or weakness

Mild dizziness

Decreased appetite

Serious Side Effects (Contact your doctor immediately):

🔴 Severe abdominal pain — may indicate pancreatitis

🔴 Skin rash, itching, swelling of face or lips — signs of allergic reaction

🔴 Muscle pain, weakness, or breathing difficulty — possible lactic acidosis (rare but serious)

🔴 Persistent vomiting or unusual fatigue — seek immediate medical attention

Not all patients experience side effects. If any discomfort persists, consult your doctor promptly.

How to Use ISTamet 50mg/500mg Tablet (Sitagliptin 50mg + Metformin 500mg)

Swallow the tablet whole with a full glass of water

Do not crush, break, or chew the tablet

Take at the same time every day to maintain consistent blood sugar levels

If You Miss a Dose:

Take it as soon as you remember

If it is almost time for your next dose, skip the missed dose

Never double the dose to make up for a missed one

Important Instructions:

✅ Monitor your blood sugar regularly as advised by your doctor

✅ Follow the prescribed diet and exercise plan

✅ Get regular kidney function (eGFR) and HbA1c tests done

❌ Avoid alcohol — it increases the risk of lactic acidosis

❌ Do not stop taking this medicine without consulting your doctor

Safety Information and Precautions for ISTamet 50mg/500mg Tablet (Sitagliptin 50mg + Metformin 500mg)

Who Should NOT Take This Medicine:

Patients with Type 1 Diabetes or Diabetic Ketoacidosis

Severe kidney disease (eGFR below 30 mL/min)

Severe liver disease or cirrhosis

Known allergy to Sitagliptin or Metformin

Pregnant or breastfeeding women (consult your doctor)

Special Precautions:

Situation What To Do

Before CT Scan / Angiography (contrast dye) Stop 48 hours before; resume only after doctor's advice

Before any surgery or procedure Inform your doctor and surgeon

During fever, vomiting, or diarrhea Consult doctor — temporary dose adjustment may be needed

If you consume alcohol regularly Reduce or stop alcohol; discuss with your doctor

Kidney or liver disease history Regular monitoring of organ function is essential

Drug Interactions (Inform your doctor if you are taking):

Diuretics (water pills)

Corticosteroids (e.g., Prednisolone, Dexamethasone)

Certain antibiotics or antifungals

Thyroid medications

Any other anti-diabetic medicines

Pregnancy & Breastfeeding:

This medicine is generally not recommended during pregnancy or breastfeeding. Consult your doctor for a safer alternative.

Storage Instructions:

🌡️ Store below 25°C at room temperature

💧 Keep away from moisture, heat, and direct sunlight

🧒 Keep out of reach of children

📅 Do not use after the expiry date printed on the pack

⚕️ Disclaimer: This information is provided for educational purposes only. Always consult a registered medical practitioner before starting, stopping, or changing any medication. NamoPharmacy.com does not recommend self-medication.