NISE MR TABLET

Uses and Benefits of NISE MR TABLET (NIMESULIDE 100MG + TIZANIDINE 2MG)

This combination is used to treat pain and muscle spasm that occur together, such as in acute back pain, neck pain, sprains, and other musculoskeletal disorders.

WHAT THIS MEDICINE IS USED FOR

• Relief of pain and inflammation from muscle or joint injuries
• Relief of muscle spasm associated with painful conditions
• Short-term management of acute low back pain and neck pain
• Post-injury or post-strain pain with muscle tightness

HOW IT WORKS

• Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, swelling and fever by blocking chemicals called prostaglandins
• Tizanidine is a muscle relaxant that acts on the central nervous system to reduce muscle spasm and tightness
• Together they relieve pain and relax tense muscles at the same time

WHAT IT IS NOT USED FOR

• Not used for chronic long-term pain management without medical supervision
• Not a treatment for infections or fever alone
• Not recommended for children
• Not meant for regular daily use without doctor's advice

Side Effects of NISE MR TABLET (NIMESULIDE 100MG + TIZANIDINE 2MG)

COMMON SIDE EFFECTS

• Nausea
• Stomach discomfort or acidity
• Drowsiness or sleepiness
• Dizziness
• Dry mouth

LESS COMMON SIDE EFFECTS

• Diarrhoea or constipation
• Low blood pressure
• Weakness or fatigue
• Headache

SERIOUS SIDE EFFECTS — STOP AND SEE A DOCTOR IMMEDIATELY

• Yellowing of eyes or skin, dark urine (signs of liver problems)
• Black or bloody stools, vomiting blood
• Severe skin rash, blistering, or swelling of face/lips/throat
• Fainting, very low blood pressure, or irregular heartbeat
• Difficulty breathing
• Significant reduction in urine output

This is not a complete list. Report any unusual or persistent symptom to your doctor or pharmacist.

How to Use NISE MR TABLET (NIMESULIDE 100MG + TIZANIDINE 2MG)

HOW TO TAKE IT

• Take this medicine exactly as prescribed by your doctor, usually after food to reduce stomach upset
• Swallow the tablet whole with water; do not crush or chew unless advised
• Do not increase the dose or take it more often than prescribed
• Avoid alcohol while taking this medicine as it can increase drowsiness and stomach irritation
• Use for the shortest duration needed to control symptoms, as advised by your doctor

IF YOU MISS A DOSE

• Take the missed dose as soon as you remember
• If it is almost time for your next dose, skip the missed one and continue your normal schedule
• Do not take double doses to make up for a missed one

STORAGE

• Store at room temperature, away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack

Safety Information and Precautions for NISE MR TABLET (NIMESULIDE 100MG + TIZANIDINE 2MG)

This is a prescription-only medicine in India and should not be used without a doctor's advice.

DO NOT TAKE THIS MEDICINE IF YOU

• Are allergic to Nimesulide, Tizanidine, or other NSAIDs
• Have active stomach ulcers or gastrointestinal bleeding
• Have severe liver or kidney disease
• Are pregnant or breastfeeding
• Are taking certain blood pressure medicines called strong CYP1A2 inhibitors

TELL YOUR DOCTOR BEFORE STARTING IF YOU

• Have a history of liver or kidney problems
• Have heart disease or low blood pressure
• Have asthma or history of allergic reactions to painkillers
• Are taking blood thinners or other pain medicines
• Are elderly or have any chronic illness

MEDICINES THAT CAN INTERACT

• Other NSAIDs or painkillers
• Blood pressure–lowering medicines
• Blood thinners like warfarin
• Oral contraceptives and certain antibiotics (e.g., ciprofloxacin) that raise Tizanidine levels
• Sedatives or alcohol, increasing drowsiness

FREQUENTLY ASKED QUESTIONS

Can I take this medicine on an empty stomach?

It is best taken after food to avoid stomach irritation, unless your doctor advises otherwise.

Can I drive after taking this medicine?

No, it can cause drowsiness and dizziness, so avoid driving or operating machinery.

Is this medicine safe for long-term use?

• It is generally meant for short-term relief of pain and spasm; long-term use should only be under medical supervision.
• Doctor ya pharmacist se salah lein.